https://rd.uffs.edu.br/handle/prefix/7 2026-05-31T09:12:07Z 2026-05-31T09:12:07Z Munzi, Amanda de Sá https://rd.uffs.edu.br/handle/prefix/9337 2026-05-25T16:46:23Z 2026-01-01T00:00:00Z

Título: Educação infantil no município de Chapecó-SC: continuidades e mudanças na história das propostas pedagógicas Autor(es): Munzi, Amanda de Sá Primeiro Orientador: Alves, Solange Maria Abstract/Resumen: La presente disertación, vinculada a la línea de “Formación de profesores, conocimiento y prácticas educativas” de la Maestría en Educación de la Universidade Federal da Fronteira Sul, al Grupo de Estudios e Investigación Escuela de Vigotski - GEPEVI y al proyecto de investigación Educación y Desarrollo Humano desde la Perspectiva Histórico-Cultural, presenta la síntesis posible, resultado de una investigación que se ocupó de analizar las concepciones de niño, infancia y práctica docente que orientaron los Proyectos Político- Pedagógicos (PPP) y los Currículos Base de la Educación Infantil (CBEI) de la red municipal de Chapecó a lo largo de los últimos 20 años, con foco en la Educación Infantil. En este sentido, tuvo como objetivo principal: analizar las concepciones de niño, infancia y práctica docente presentes en los Proyectos Político-Pedagógicos de la educación escolar del municipio de Chapecó a lo largo de los últimos 20 años. El abordaje del objeto y del objetivo se orientó mediante el análisis documental, guiado por los presupuestos del método del Materialismo Histórico-Dialéctico (MHD) y de la Teoría Histórico-Cultural (THC), comprendiendo el objeto como un fenómeno histórico y en constante movimiento. Bajo esta orientación, se realizó una investigación documental con análisis de contenido de 13 documentos, entre revistas educativas, Proyectos Político-Pedagógicos y Currículos para la educación municipal publicados entre 1998 y 2024. Los resultados demuestran que la trayectoria de la Educación Infantil en Chapecó pasó por transformaciones significativas: desde un carácter asistencialista y de subsistencia básica en la década de 1980, avanzando hacia la institucionalización de la modalidad bajo la perspectiva de la Educación Popular (influenciada por Paulo Freire) entre 1997 y 2004, hasta la estructuración de currículos basados en la THC y, más recientemente, alineados con la Base Nacional Común Curricular (BNCC). Los análisis revelan que, aunque los Currículos Base de la Educación Municipal actuales (2019 y 2023) incorporan el protagonismo infantil y la escucha activa como ejes centrales, el papel del profesor permanece fundamental como mediador entre el niño y el conocimiento históricamente producido, con el objetivo de promover el desarrollo integral en la primera infancia. Instituição: Universidade Federal da Fronteira Sul Tipo: Dissertação

2026-01-01T00:00:00Z Carmo, Rafael de Lima https://rd.uffs.edu.br/handle/prefix/9336 2026-05-25T16:43:59Z 2026-01-01T00:00:00Z

Título: Concordância entre as medidas da versão brasileira da Palliative Care Outcome scale (POS) nas versões paciente e cuidador Autor(es): Carmo, Rafael de Lima Primeiro Orientador: Conceição, Vander Monteiro da Abstract/Resumen: Introduction: According to the World Health Organization, palliative care is recommended for people diagnosed with a life-threatening illness. Therefore, as the number of people with chronic noncommunicable diseases, such as cancer, increases, so does the need for healthcare professionals to provide palliative care. Understanding the palliative care needs of these individuals is essential for providing quality healthcare. Assessing these needs using valid and accurate tools is fundamental for both diagnosis and evaluation of the care provided. The use of these measurement tools to assess the perceptions of these individuals and their caregivers is necessary for both clinical care and research. As the health condition of cancer patients worsens, it is not always possible to obtain an assessment of palliative care needs directly from the patients themselves. An assessment obtained through their caregiver may be the only viable alternative. Aim: Analyze the agreement between the scores obtained from the Brazilian versions of the Palliative Care Outcome Scale (self-report and caregiver versions), administered respectively to people diagnosed with cancer and their caregivers. Method: A cross-sectional methodological study. Data collection took place in the inpatient units of the Oncology Department at a regional referral hospital specializing in cancer treatment. The study population consisted of individuals with any cancer diagnosis and their informal caregivers who were undergoing treatment at the study site, regardless of disease stage. The sample consisted of 206 participants, including 103 people with cancer and 103 of their respective informal caregivers. Sociodemographic and clinical data were collected through individual interviews and review of patients’ electronic medical records. Patients and caregivers were interviewed and individually completed the POS-self and POS-carer versions, respectively. For the analysis of the collected data, descriptive statistics were used, including measures of central tendency, frequency, and percentage, along with inferential statistics via the paired t-test to compare measures between the two groups. The level of significance adopted was less than 0.05. The research project was approved by the Human Research Ethics Committee, see opinion number 7.401.113 and CAAE: 85736325.4.0000.5564. Results: There was an equivalent average score on the variables presented by the POS among participants with cancer and their respective informal caregivers, with statistical evidence (p = 0.003) of a difference in the assessment of anxiety related to treatment or the disease. In this regard, agreement in the assessment of palliative care needs between the pair is predominant, with a divergence regarding anxiety, a psychological variable of the instrument. Conclusion: People with cancer and their respective informal caregivers show agreement in the POS measures, with the exception of the assessment of psychological aspects, where there may be an overestimation in the informal caregiver’s assessment. Instituição: Universidade Federal da Fronteira Sul Tipo: Dissertação

2026-01-01T00:00:00Z Rosa, Vandriel Pedone da https://rd.uffs.edu.br/handle/prefix/9334 2026-05-21T12:34:25Z 2026-01-01T00:00:00Z

Título: Inibição do gene CD73 em linhagem de câncer de bexiga: uma estratégia terapêutica de resposta a quimioterápicos que atuam na biossíntese de purinas Autor(es): Rosa, Vandriel Pedone da Primeiro Orientador: Maciel, Sarah Franco Vieira de Oliveira Abstract/Resumen: The ectonucleotidase CD73 has been widely recognized as an important modulator of the tumor microenvironment, mainly due to its role in the conversion of AMP into adenosine, promoting immunosuppression and favoring tumor progression. The present study aimed to correlate CD73 expression as a biomarker of cell viability in response to treatment with cell death– inducing chemotherapeutic agents, such as cisplatin, paclitaxel, and doxorubicin, in the T24 bladder cancer cell line, using a strategy of protein translation modulation through RNA interference, as well as a CD73 knockout T24 cell line. Gene expression analysis did not demonstrate increased CD73 expression in the T24 tumor cell line compared to a set of non- tumoral bladder tissue samples used as control. In contrast, protein expression showed a reduction after RNA interference treatment, confirming modulation at the transcriptional level. In cell viability assays, the isolated or combined application of chemotherapeutic agents in the unmodified T24 cell line did not show a significant effect. After CD73 silencing by RNA interference, a change in the drug response profile was observed. Combinations such as cisplatin + paclitaxel and cisplatin + doxorubicin resulted in a significant reduction in cell viability at all tested concentrations, indicating a potentiated cytotoxic effect under conditions of purinergic pathway modulation. In the CD73 knockout T24 cell line, the isolated application of paclitaxel and cisplatin did not promote a significant reduction in cell viability, while doxorubicin at the lowest concentration maintained a cytotoxic effect. In this cell line, combined treatments generally did not show consistent significant reductions in cell viability, suggesting that the absence of CD73 may alter the response to combination therapies. Overall, the results indicate that CD73 silencing or inhibition plays a relevant role in modulating cellular response in the presence of the chemotherapeutic agents cisplatin, doxorubicin, and paclitaxel, whether used alone or in combination, influencing resistance or sensitivity mechanisms depending on the experimental context and therapeutic strategy adopted. Thus, CD73 stands out as a potential biomarker and promising therapeutic target in bladder cancer Instituição: Universidade Federal da Fronteira Sul Tipo: Dissertação

2026-01-01T00:00:00Z Kajewski, Odair J. M. https://rd.uffs.edu.br/handle/prefix/9333 2026-05-19T18:31:54Z 2026-01-01T00:00:00Z

Título: O papel do gestor na implementação das novas tecnologias educacionais: desafios da formação continuada nos espaços escolares Autor(es): Kajewski, Odair J. M. Primeiro Orientador: Silva, Denilson da Instituição: Universidade Federal da Fronteira Sul Tipo: Artigo Cientifico

2026-01-01T00:00:00Z