Revisão bibliográfica sobre o potencial antitumoral do resveratrol para gliomas

Abstract

This paper aims is to make a literature review on the potential of Resveratrol (Rsv), a polyphenol found in red wine with beneficial effects on human health, as potential chemotherapy for glioblastoma (GBM), which are primary malignant brain tumors and result in large mortality. It is a descriptive, qualitative and developed study from literature reviews on the topic related to GBM and the action of Rsv as antitumor. Scientific articles available on PubMed website published between 2000 and 2015 were used. The key words "Resveratrol and glioma" and "Resveratrol and glioblastoma” were applied. 81 articles demonstrating the antitumoral potential of Rsv in in vivo and in vitro models of GBM were found with several effects on cellular and molecular parameters. The articles showed in vitro cytotoxicity effect of RSV in human glioma lines, rats and mice, induction of apoptosis, necrosis and cell cycle arrest. The main signaling pathways that RSV modulated to exert this antitumor effect were the PI3-K pathways, ERK and mTOR. In vivo studies have shown that Rsv treatment was able to reduce tumor growth and prolong survival of animals that received an intracranial implant of these tumors. None of the published articles found toxic potential of Rsv in their studies. This paper showed that the Rsv has great potential as a chemotherapeutic or adjuvant for the treatment of GBM and it is a strong candidate to human clinical trials to treat this so aggressive and fatal disease.