Análise imuno-histoquímica em carcinomas de células renais: estudo da proteína PD-L1

Abstract

To characterize patients with Renal Cell Carcinoma (RCCs) undergoing radical or partial nephrectomy or renal biopsy and to evaluate the expression of PD-L1 protein in tumor tissues and relate to clinical and pathological data. Methods: This is a cross-sectional study, which included all cases of CCRs from 2000 to 2015 analyzed in the Pathology laboratory of a reference hospital in northern Rio Grande do Sul. Sociodemographic, clinical and pathological data were obtained from medical records. The expression of PD-L1 was determined using the technique of Tissue Microarray Analysis and immunohistochemistry, and related to the observed clinical-pathological characteristics. Results: a total of 167 cases of RCC were identified, of which 89.1% were clear cells. It was notethat 69.5% of the patients were male, 54.5% in the 60-79 years age group and 31.7% smokers. According to clinical staging (NMT), 55.8% of the cases found were in Stage I. Furthermore, the positivity of the PD-L1 protein was associated with a higher chance of death (p<0.05) and a shorter survival (p<0.05). Conclusions: In addition, to well know prognostic indicators, such as TNM and Fuhrman Degree, PD-L1 has the potential to be used as a prognosis in CCRs.