Análise do estresse oxidativo e do sistema purinérgico em gestantes hipertensas no Município de Chapecó

Abstract

Pregnancy is a physiological event, as well as a period of many expectations and questions, constituting a unique moment in the lives of many women. However, some women may present complications during pregnancy, among them, we can highlight Gestational Hypertension (HG) as causing several harmful effects to the maternal, fetal and neonatal organism. In this sense, recent studies indicate that there is a close relationship between hypertension and the purinergic system. This system is composed of nucleotides, enzymes and receptors that together help maintain vascular integrity as well as the regulation of the immune system respectively. In addition, the woman during the gestational period has increased oxygen, which may culminate in reactive oxygen activities, as well as the failure of antioxidant protection mechanisms, which results in oxidative damage. The methodological course was of quantitative approach and experimental character. Purinergic system analysis for ectoenzyme activity was evaluated by hydrolysis of adenine nucleotides (ATP, ADP and AMP) and adenosine nucleoside in blood samples of lymphocytes and platelets. Thus, in this study the evaluation of ATP and ADP hydrolysis indicated a higher activity of NTPDase in lymphocyte cells in pregnant women with HG. Pregnant women with HG had increased adenosine levels in both lymphocytes and platelets. Thus, it was possible to evaluate the components of the purinergic system and to verify that they participate in hemostatic control during pregnancy. It is concluded that with the results obtained that these components help in vascular regulation and endothelial alterations susceptible to this period. Additionally, regarding the oxidative profile parameters of the studied population, they presented the production of reactive oxygen species during the gestational period, which contribute to the cellular damage. Nevertheless, it was observed that the maternal body reacts effectively through its antioxidant protections to ensure homeostatic stability.