O efeito antitumoral do extrato de annona muricata: uma revisão sistemática

Abstract

This completion of course work in article format is a systematic review aimed at analyzing the antiproliferative, anti-inflammatory and apoptotic potential present in extracts of Annona Muricata, with a greater focus on acetogenins. The study of these compounds is justified by the need to subsidize the development of new drugs to combat tumor development to cause the least possible damage to the body. The research was conducted by searching for articles in the Pubmed and Scielo databases in the time interval from 2010 to 2023. The results showed that the acetogenins present in the species Annonaceae stand out and represent a great pharmacological potential in the fight against due to its antiproliferative action through the induction of apoptosis by inhibition of the mitochondrial complex I of the electron carrier chain, in addition to other mechanisms of action involved. The studies analyzed in this review indicate the anticancer potential present in the extracts of Annona Muricata, however it is still necessary more in vivo studies to clarify the mechanisms of action of the different extracts present in the plant.