Efeitos do treinamento físico em circuito sobre os componentes do sistema purinérgico e parâmetros de estresse oxidativo em mulheres com diabetes mellitus tipo 2

Abstract

Type 2 diabetes mellitus (T2DM) is an important cause of morbidity and mortality in Brazil and worldwide. It is a very prevalent chronic disease, characterized by a hyperglycemic state resulting from insulin resistance in peripheral tissues. It is well established that the prothrombotic state is an important factor in the morbidity and mortality of the disease, and purinergic signaling and oxidative stress can increase these processes. Taking this into account, physical exercise can beneficially modulate these components, however, the effects of mixed circuit training on purinergic and oxidative aspects of women with T2DM have not been studied before. Therefore, we investigated the effect of a 16-week mixed circuit physical training protocol on platelet ectonucleotidases, as well as levels of oxidants, antioxidants, and adenosine triphosphate (ATP) in the serum of women with T2DM, these were evaluated before and after the intervention of physical exercise, both in the diabetes group and in the control group. In platelets, after the intervention, there was a reduction in the activity of the enzyme ectonucleotidase diphosphohydrolase (E-NTPDase) when the substrate was adenosine diphosphate (ADP) and also decreased levels of extracellular ATP. In addition, exercise promoted an increase in antioxidants and a decrease in oxidants defenses. Therefore, physical exercise of the mixed type in circuit proved to be a valuable strategy in the modulation of essential components for controlling T2DM in women in favor of an anti-aggregation pattern.