O uso da biópsia do linfonodo sentinela na avaliação do estágio patológico do câncer de colo uterino

Abstract

Objectives: To document the use of the sentinel lymph node biopsy technique in patients with cervical cancer. Evaluate the sentinel lymph node localization rate using double labeling (patent blue and technetium 99m); To compare clinical, anatomopathological and survival variables of patients undergoing sentinel lymph node biopsy with patients undergoing pelvic lymphadenectomy (control group). Methodology: This is an observational, retrospective cross-sectional study. Furthermore, the study integrates both quantitative and qualitative elements to obtain what is proposed in the objectives, extrapolating the interpretation of data and applying the results in clinical practice. Data from all patients undergoing total hysterectomy extended with SLNB were included in the analysis. For reasons of comparison, the variables of patients undergoing total hysterectomy extended with conventional LP were evaluated; Results: It was possible to evaluate data from 22 patients, of which 12 patients underwent total hysterectomy and radical LP, and 10 underwent total hysterectomy and SLNB, and in this group, 1 patient had a positive lymph node and underwent complementary radical lymphadenectomy. The average age was 38.64 years (30 years to 68 years). The majority histology of the neoplasms was squamous cell carcinoma (16 patients, 72.73%) and the most frequent FIGO 2018 stagings were IA1 and IB1 (5 patients, 22.73%; 5 patients, 22.73%). In total, 26 sentinel lymph nodes were collected, with an average of approximately 3 lymph nodes per patient [1-9]. Pathological analysis indicated 3 patients (16.67%) with parametrial involvement, 2 patients (10.53%) with vaginal invasion and 10 patients (50%) with lymphovascular space invasion. 4 patients (18.19%) had positive margins. Conclusion: The absence of significant differences in the variables analyzed reinforces the potential clinical usefulness of sentinel lymph node biopsy as a standard procedure in the evaluation and treatment of cervical cancer.