Hormônio estrogênio na água provoca alterações comportamental e desregulação endócrina em Zebrafish

Abstract

Nowadays drug use has increased, among them are oral contraceptives, which are synthetic hormones ingested daily by millions of women worldwide. Considering the environmental problem related to the disposal of non-metabolized synthetic hormones in waste water, a biomagnification can occur at the toxicant due to the fact that the hormones return to the environment in its original form reaching aquatic organisms, and may reach the man. The objective was to evaluate the possible effects of acute and chronic exposure via social behavior type, anxiety, and aggression, and possible effects on the endocrine system, using the zebrafish as a model organism. We can conclude that the results obtained are alarming, since the 17-alpha-ethinyl estradiol hormone is detrimental to the experimental model used, both to its endocrine system and behavior. In chronic exposure occurred change in social behavior type, anxiety, and make it more aggressive. There were also changes in the endocrine system, altering levels of estradiol and testosterone. Thus we believe that these results show damage to the organism both in relation to the behavior of the specie, as its endocrine system. The presence of 17-alpha-ethynylestradiol in the water has a negative impact on the behavior of the organism analyzed. Potentially putting at risk not only the organism studied, as well as various species and populations developing. This can cause a severe ecological impact on the system exposed to this hormone.