Estudo da clivagem de DNA por complexos metálicos que atuam como nucleases sintéticas

Abstract

This work aimed to broaden knowledge in the area of bioinorganic chemistry, more specifically, metallic complexes that act as synthetic nucleases cleaving the bonds of DNA and that can assist in the treatment of cancer. For this, a bibliographical revision was carried out in books, articles, theses and dissertations that report how complexes perform the cleavage of the DNA, and which analyses performed to understand this behavior. The most current in the study of these complexes (synthetic nucleases) was sought. After the search in the literature, two articles were chosen containing complex dinuclears for analysis, one of them reports the study of the complex [Fe III Zn II (LP2)(μ-OH)(H 2 O)], called the FeZn complex, which mimics the enzyme phosphatase acid purple (PAP), and performs the Cleavage of the DNA by the Hydrolytic method. The second article reports the study of the copper(II) dinuclear complex, [Cu2 (Apyhist) 2 (dpam)], called Cu2, which mimics the enzyme tyrosinase by the oxidative method for its cleavage activity.