Resveratrol e câncer de colo do útero: revisão

Abstract

Cervical cancer is a public health problem in most developing countries and also in developed countries. In Brazil, estimates by the National Cancer Institute (INCA) for the years 2016-2017 point to the occurrence of 16340 new cases of cervical cancer. Today much is known about the pathogenesis of this cancer and its precursor lesions. It is recognized, for example, that Human Papillomavirus infection is imperative in this process. Resveratrol is a plant compound found mainly in grape and red wine and has several beneficial effects on human health, being a potential antitumor molecule. Thus, the objective of this work is to perform a bibliographic research about the potential of Resveratrol as a chemotherapeutic for cervical cancer. For this, a descriptive, qualitative study was carried out based on bibliographic reviews on the subject related to cervical cancer and the chemotherapeutic potential of Resveratrol. Scientific articles available on the Pubmed, Scielo and Scopus website were used in this research process. The reference period used was between 2012 and 2017. The main keywords used in the search for references were: cervical cancer and Resveratrol. After the review, 20 articles were found that fit the established criteria. As a result, the review showed several studies in which Resveratrol has apoptosis-inducing activity, cytotoxic effect, causes cell cycle arrest and cell death, indicating that Resveratrol has potential to be applied in clinical practice.