Síntese de 2-Organocalcogenil-indóis via reações de ciclização mediadas por WERSA

Abstract

In view that heterocyclic compounds, such as indoles, as well as organochalcogen derivatives may present interesting biological activities, such as anti-inflammatory, analgesics and antioxidant, this work consists of a study of a methodology with potential for the synthesis of 2-organocalcogenyl-indols containing selenium atoms.. Therefore, the studies were focused on determining an ideal condition to promote the cyclization reaction of 4-cloro-2- phenylethinyl-aniline to obtain the 2-phenylselanyl-indol. Through this synthetic protocol, with the use of WERSA in a reaction medium that corroborates with the principles of Green Chemistry, it is hoped to enable a new methodology for obtaining indole compounds that contain selenium, sulfur or tellurium atoms in their structures.