Revisão de metodologias para a síntese de heterociclícos por meio de reações de ciclização de compostos alquinílicos promovidas por reagentes eletrofílicos

Abstract

The present work consists of a bibliographical review on the synthesis of heterocycle from electrophilic cyclization reactions in alkylinyl compounds. Heterocycle are present in a variety of natural and synthetic substances exhibiting important pharmacological activities. Many of these methods described for the synthesis of heterocycles use drastic conditions and make use of transition metals. Due to these factors, the objective of this review is to explore efficient methodologies with cleaner and less energetic reaction conditions for the synthesis of different heterocycles. The research for articles was carried out in the Web of Science, delimiting articles published within the last ten years. We found articles with efficient methodologies for the synthesis of several heterocycles, but in most cases there is a need for high temperatures for the products to be obtained with good yields.