Análises imuno-histoquímica e sérica de marcadores tumorais em adenocarcinomas pancreáticos

Abstract

Introduction: Pancreatic adenocarcinoma coincide with approximately 90% of tumors in pancreas. It has an indolent evolution, rapid dissemination and an aggressive course with difficult detection. Ki-67 antigen is related to cell proliferation and can help in the analysis of progression and prognosis of several tumors. Objective: to evaluate the expression of tumor marker Ki-67 and correlate it with clinical and pathological characteristics, prognosis and survival of selected patients. Material and Methods: Cross-sectional study, the cases were selected by patients diagnosed with pancreatic adenocarcinoma who had biopsy or pancreatectomy speciment in the pathology laboratory of a tertiary hospital, in the period from 2000 to 2015. They were evaluated for the immunohistochemical reaction of Ki-67 protein and their clinicopathological characteristics, and the significance level adopted was 5%. Results: In the period considered, 27 patients with pancreatic adenocarcinoma were identified, and the most prevalent clinical and epidemiological characteristics were male (55.6%) with a mean age of 63 years ± 8.9, smokers or former smokers in the time of diagnosis (63.2%). Ductal adenocarcinoma was the most prevalent (94.4%), moderately differentiated (50%), with anatomical location in the head of the pancreas (87.4%) and in more advanced stages, III and IV (66.6%). The Ki-67 positivity was 92.6% of the cases. In addition, 77.8% of patients died, and 81% died within 12 months. Ki-67 expression >20% was significantly correlated with younger age of patients. Conclusions: A high prevalence of Ki-67 antigen expression was found in pancreatic adenocarcinomas, however, its expression was only associated with patient age, therefore, further studies are needed to confirm the prognostic value of this tumor marker.