Análise bioquímica do estresse oxidativo e sistema purinérgico em gestantes com diabetes mellitus gestacional

Abstract

Pregnancy is characterized as a physiological period in which there is a greater sensitivity to insulin resistance and changes in oxidative stress. Purinergic signaling is directly related to diabetes, as this condition modifies the concentration of extracellular ATP and the level of degradation of ATP to adenosine. Thus, the objective of this study was to analyze the oxidative stress and purinergic system in pregnant women with gestational diabetes mellitus (GDM) and compare them with low risk pregnant women (BR). The research was of quantitative approach, of experimental character. The study was conducted in two moments, first in a clinic in the west of Santa Catarina, which serves pregnant women with gestational diabetes mellitus (GDM). And in a second moment it was in the Chapecó Family Health Centers. Results: Oxidative stress was higher in low risk pregnant women when compared to GDM. This fact occurred because antioxidant defenses were increased in pregnant women with GDM. In the purinergic system, there was a significant difference in pregnant women with GDM when compared to pregnant women in BR, with a change in nucleotide hydrolysis by enzymes in platelets.