Ação antitumoral da curcumina na viabilidade celular em linhagem de câncer de mama – mda-mb-231: revisão sistemática

Abstract

Cancer is one of the leading causes of mortality in the world, with approximately 18 million new cases and 9.6 million deaths in 2018. It is the most common malignant tumor in women in the world, and the second most diagnosed in the general population, second only to lung cancer. Metastatic breast cancer, so far, has no cure, accounting for the vast majority of deaths caused by this disease. Different research on natural components to control the multiplication of breast cancer cells have been published in recent years, including curcumin - a polyphenol with important biological activities in cancer. Cell cultures are one of the approaches used to study antitumor effects of substances, especially the MDA-MB-231 cell line, which represents an aggressive phenotype of metastatic breast cancer. Thus, the present work sought to review the action and effects of curcumin, and derivatives, on the MDA-MB-231 cell line. For this, scientific articles from PubMed, LILACS, BVS and Scielo databases were analyzed, without limitation of year. Studies that had the descriptors (cancer de mama or breast cancer) and (metástase or neoplasm metastasis) and (curcumina or curcumin) and that met the objective proposed by this research were included. Evidence demonstrates that the most used methodology to assess cell line viability was the MTT assay (3-4,5-dimethyl-thiazol-2-yl-2,5-diphenyltetrazolium bromide). The most prevalent dilution in the literature is curcumin purified from turmeric with a purity greater than 95%, and the most used treatment to assess the effects on the cell line is at a concentration of 20μM. Evidence supports the anti-proliferative, pro-apoptotic, anti-metastatic and anti-inflammatory effects of curcumin.