Associação entre exposição pré-natal aos agrotóxicos e a ocorrência de transtornos do neurodesenvolvimento em crianças: uma revisão sistemática e metanálise

Abstract

There is growing evidence that associate exposure to pesticides with health problems, including neurodevelopmental disorders. The aim of the present research is to analyze the relationship between prenatal exposure to pesticides and the occurrence of neurodevelopmental disorders in a systematic review. This systematic review and meta-analysis is registered in PROSPERO number RD42022361861. The Data Sources were PubMed and Embase. Only human studies that assess prenatal exposure of pregnant women to pesticides used in agriculture and the occurrence of neurodevelopmental disorders were included. No restrictions on language and date of publication were applied. Eight articles met the eligibility criteria. The results show an association between exposure to agricultural pesticides and the occurrence of neurodevelopmental disorders during childhood. The meta-analysis indicates that there is an association between prenatal exposure to organophosphate pesticides and the occurrence of neurodevelopmental disorders (OR = 1.1; 95%CI: 0.99 - 1.21; p = 0.07). The research points to the need for implementation of further protection from the harmful effects of pesticides in children.