Perfil epidemiológico de pacientes com hiperferritinemia e análise do subdiagnóstico de linfohistiocitose hemofagocítica

Abstract

Introduction: ferritin is a serum marker with lots of uses in medicine, and commonly is altered in diseases such as chronic renal failure. However, there are just a few studies about the epidemiologic profile of patients with ferritin alteration and its relation with poor hemodialysis outcomes. Objective: to determinate the epidemiologic profile of this population and which are the factors involved in chronic renal failure progression and prognostic. Methods: from a cross-sectional study realized with patients attended in a tertiary health service in the city of Passo Fundo/RS, Brazil, that performed at least four serum ferritin measures in the period of 2016 and 2017; the variables age, sex, ferritin levels and its relation with the outcomes elevated creatinine and elevated Creactive protein were analyzed. Besides that, the determination of the most prevalent disease was determinate. Results: chronic renal failure is the most prevalent pathology founded, present in 73% of the patients. Hematologic disturbs and gynecologic/obstetric hospitalizations are de second most prevalent pathology, with 5% of prevalence each. Among patients with chronic renal failure, the male sex and being more than 60 years are factors with statistical significance for the outcome elevated creatinine. Ferritin levels don’t seem to influence the outcomes analyzed. Conclusion: Chronic renal failure is the most common pathology among patients analyzed. Among these, serum ferritin doesn’t seem to have influence on the increase of creatinine in hemodialysis or intra peritoneal dialysis patients. Also, it doesn’t have relation with the increase of Creactive protein. Therefore, this serum marker doesn’t have a big influence on the monitoring of morbidity and mortality due to the loss of residual renal function during hemodialysis.