Reações de ciclização de 2-((organoselenil)etinil)anilinas promovidas por iodo molecular

Abstract

This work reports the study and development of a methodology to promote intramolecular cyclization reactions of 2-((organoselenyl)ethynyl)anilines, employing molecular iodine as a cyclization promoting agent, which provides of mld and ecofriendly reaction conditions. Using this methodology, the objective was the synthesis of a series of 2,3-bis(organoselenyl)-1H-indoles through the use of differently functionalized 2-((organoselenyl)ethinyl)anilines as starting materials. It is believed that the developed methodology was efficient to promote the cyclization of different substrates, leading to obtaining 2,3-bis(organoselenyl)-1H-indoles in up to 99% yield. In addition, a bibliographical study complementary to the experimental work was carried out and made it possible to write a manuscript, which is exposed in the form of an article, which consists of an overview of the most recent advances in the synthesis of carbo- and heterocycles containing organochalcogens, by reaction of diorganyl disulfides, diselenides and ditellurides with alkynyl compounds in the presence of copper and iron salts to promote cyclization reactions.