Evidências bioquímicas e patológicas da euritrematose como causa primária de diabetes mellitus tipo I

Abstract

he Eurytrematosis is a helmintic is a disease caused by trematodes belonging to the genus Eurytrema that parasitize the pancreas of various domestic animals and humans. This parasite causes chronic fibrosing pancreatitis, fat infiltration into the pancreatic parenchyma, as well as the compromise of the exocrine pancreas, with progressive destruction of the islets of Langherans, similar to that found in patients with Type I Diabetes Mellitus. To evaluate the use of bovine pancreas as an animal model for the study of pathophysiology of diabetes mellitus type I. Analyzes were performed to determine total pancreatic lipid, Langherans Islet biometry and insulin expression by pancreas β cells naturally infected with E. coelomaticum . It was verified in the macroscopic analysis that the pancreas of infected animals had obstruction of ducts with countless adult parasites, stiffening of the organ by the visible presence of fibrosis, increased deposition of adipose tissue, reduction of the islet area of Langerhans, and reduction of Expression of insulin. From these results we can conclude that Diabetes Mellitus can have pancreatic parasitism as a primary source, but it is necessary to develop more research that demonstrates the endocrine and exocrine mechanisms involved in the infection.