Biomarcadores cardiovasculares em mulheres histerectomizadas e terapia de reposição hormonal

Abstract

Introduction: Hormone replacement therapy (HRT) is an intervention used for menopausal women to control the symptoms associated with the physiological modifications presented during this phase. Hysterectomy is a procedure that causes an increased risk for cardiovascular diseases (CVD) when compared to non-hysterectomized women. The effects of HRT over the biomarkers in CVD in this group of women at higher risk have not been well defined. Objective: Summarize the results of randomized controlled trials (RCT) evaluating the effects of HRT on the biomarkers in CVD of hysterectomized menopausal women. Methods: A systematic review following the PRISMA model and registered in the PROSPERO platform was developed, evaluating RCT selected from the scientific bases PubMed, Scopus, and Web of Science. Results: 7 articles were included for analysis, demonstrating a rise in the levels of HDL and reduction of the levels of LDL, total cholesterol, glucose, insulin, and fibrinogen of patients; maintenance or rise in the levels of CRP and inconclusive findings regarding BP alterations. Conclusion: HRT can offer important benefits for the cardiovascular status of this group of patients and must be prescribed according to each patient's needs and characteristics.