Uso do enxaguante bucal de Plantago Major L. nas mucosites orais relacionadas ao câncer: um ensaio clínico randomizado duplo cego

Abstract

Oral Mucositis (OM) is a common intercurrence in patients undergoing treatment for cancer and is routinely debilitating, and its treatment is one of the priorities in clinical oncology. The objective of this work was to formulate and evaluate the effects of a mouthwash with Plantago major L. extract (tansagem) applied as a mouthwash in patients with mucositis induced by chemotherapy and radiotherapy. The tansagem is part of a list composed of 71 plant species with potential to promote health and of interest to MS, it is an invasive plant that belongs to the Plantaginaceae family and is widely used in traditional medicine. This is a randomized clinical study comparing the use of a mouthwash based on tansagem with a mouthwash based on chlorhexidine (control), carried out with 11 participants, divided by simple randomization through the Microsoft Excel Program of an Oncology Clinic in the Southwest of Paraná , lasting 53 days. The oral evaluation of patients who had mucositis was performed weekly, on days 0, 7 and 14 during treatment with daily mouthwashes with mouthwashes (3x a day). For purposes of analysis and elaboration of the mouthwash, hydroalcoholic extraction of the plant was carried out, as well as its characterization regarding the content of phenolic compounds, antioxidant (DPPH, ABTS, FRAP), antimicrobial activity and evaluation of cytotoxic potential in cell lines. The tansage presented values of phenolic compounds of 19.64 (±0.38) and of antioxidant activity DPPH 444.12 (±0.759), FRAP 3848.11 (± 84.46) and ABTS 10435.19 (± 447.63 ). As for the cytotoxicity analysis, the extract did not show cytotoxic activity at concentrations of 0.06, 0.6 and 6mg/mL. In the antimicrobial evaluation, tansage had a bacteriostatic response. In the comparison with the use of the mouthwash based on chlorhexidine and the mouthwash based on P major, there was no significant difference between one mouthwash and the other, in relation to pain and degree of mucositis, thus showing that the mouthwash based on tansage, to be an option of choice in the preventive and prophylactic use of mucositis lesions caused by chemotherapy treatment in cancer patients.